Purpose: To evaluate the dissolution and permeation characteristics of artemether tablets formulated\nwith cashew and prosopis gums, and compare with tablets prepared with acacia gum.\nMethods: Artemether tablets containing varying concentrations (1.0 to 4.0 %w/w) of cashew and\nprosopis gums or 3 %w/w of acacia (control) gum as binders were formulated by wet granulation\nmethod. The tablets were evaluated for crushing strength, friability and disintegration time. Dissolution\nand permeation characteristics of the formulations were studied using USP methods.\nResults: Tablets formulated with prosopis gum had higher crushing strength, higher friability and higher\ndisintegration time compared to those of cashew gum at corresponding binder concentrations. Tablets\nformulated with 3 %w/w cashew gum exhibited complete drug release within 1 h, 95 % drug permeation\nin 188 min (in simulated gastric fluid [SGF]) and 95 % permeation in 224 min (under simulated intestinal\nfluid [SIF] condition) while those made with 3 %w/w prosopis gum exhibited 70.7 % drug release in 1 h,\n95 % permeation in 135 min (in SGF) and 95 % permeation in 170 min (under SIF condition).\nConclusion: Cashew gum is effective as a binder over a relatively wide range of concentrations to\nachieve fast drug release though with minimal permeation enhancement while prosopis gum is\ncharacterized by delayed drug release but enhanced permeation of the released drug.
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